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Central to this process is GPX4 (glutathione peroxidase 4), a selenoprotein that acts as a primary defense against phospholipid peroxidation, a hallmark of ferroptosis [2]

In a study by Benkoucha et al., HGF exerted an anti-inflammatory effect through the generation of tolerogenic dendritic cells with the consequent suppression of auto-reactive T helper cells 1 (Th1) and Th17 cells and leading to the reduction of CD4 + T-cell-mediated nervous system injury in the experimental autoimmune encephalomyelitis (EAE) animal model of MS, in which HGF was overexpressed (HGF transgenic mice) (Benkhoucha et al., 2010)

10.1016/j.amjhyper.2005.02.012 219 MalaisseW.Malaisse-LegaeF

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Work quickly but carefully to minimize room-temperature exposure